CHEMOTHERAPY-ELICITED EXOSOMAL MIR-378A-3P AND MIR-378D PROMOTE BREAST CANCER STEMNESS AND CHEMORESISTANCE VIA THE ACTIVATION OF EZH2/STAT3 SIGNALING

Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown.Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors.However, the

We show that the phase spaces of a large family of line operators in 4d Chern-Simons theory with GL$_n$ gauge group are given by Cherkis Power Supply bow varieties with $n$ crosses.These line operators are characterized by Hanany-Witten type brane constructions involving D3, D5, and NS5 branes in an $Omega$-background.Linking numbers of the five-br

Concealer Brush Water is an important element in life, both for daily activities as well as for religious interests.Therefore an ancient building called Petirthaan has a very important role for the life of community.Petirthaan is real evidence that people had protected nature and the environment by establishing Petirthaan to perform worship of wate

Predictive approaches play an important role in detecting events, controlling risks and reducing maintenance and repair costs.The purpose is to provide a model for predicting critical and prioritized risks based on data mining algorithms.Data mining method was planned based on the CRISP methodology.Data modeling has been done in two parts: "descrip